Ja, aber siehe die Photos, die sind soweit ich das einschätze eindeutig Knorpel weg, was bei MIA zu erwarten ist. Der Text ist auch eindeutig. Wie gesagt es sind halt nur 49 Ratten, aber wenn man davon ausgeht dass es eher drum ging UC II zu belegen so war das Ergebnis mit niacinamide quasi effektiver eher unerwartet, und mir scheint die Studie durchaus seriös (ganz im Gegensatz etwa zu Studien von Regenex).
Wenn du dir den vollen Text hier durchliest ist es IMHO ziemlich eindeutig dass der Knorpel sich regeneriert hat:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289820/
Insbesondere: However, rats with OA had a high score reaching grade 3 with common radiographic features, including joint space, narrowing, reduced articular space, sclerosis with articular surface irregularity, and the intense formation of osteophytes and intense osteophyte formation. The rats treated with UCII and NA alone experienced less evidence of the common radiographic features of OA, along with the scores not exceeded grade 2. However, the rats treated with UCII + NA200 had further alleviation of the scores (grade 1) along with a normal thickness of the cartilage surfaces, being able to reduce the degree of knee joint involvement in relation substantially.
The joints of the intact rats retained intact superficial and smooth articular cartilage surfaces with the underneath layer of flattened chondrocytes in the tangential zone (Fig.
4). In addition, chondrocytes of the same joints were normally distributed in parallel rows, transitional and radial zones of the articular cartilage. As expected, the rats with OA had irregular surfaces accompanied by loss of cartilage tissue degeneration of the articular cartilage and disappearance of chondrocytes in the tangential, transitional and radial zones of the cartilage. However, supplemental UCII and NA altered the histological changes in rats with OA.
